Top latest Five ceesdekker Urban news
Top latest Five ceesdekker Urban news
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Utilizing one-molecule optical and AFM imaging and pressure-spectroscopy strategies, we look for to unravel the mechanistic aspects of the composition and dynamics of chromosomes. Our investigation interests include:
Human Rad51 filaments on double- and solitary-stranded DNA: correlating normal and irregular kinds with recombination functionality.
Dynamics of initiation, termination and reinitiation of DNA translocation via the motor protein EcoR124I
Nanofabrication of electrodes with sub-5 nm spacing for transportation experiments on solitary molecules and metallic clusters
2015, discovery that condensin can be a very adaptable protein framework; and very first detection of DNA knots using nanopores
The coiled-coil in the human Rad50 DNA repair protein has certain segments of increased adaptability
We form germs into types that deviate from their natural phenotype. Specifically, I'll exhibit our capacity to shape live E. coli bacteria into novel styles which include rectangles, squares, triangles and circles.
Dynamic ParB–DNA interactions initiate and keep a partition condensate for bacterial chromosome segregation
The rotors harness Power from a nanoscale h2o and ion movement that's created by a static chemical or electrochemical likely gradient inside the nanopore, that are established by way of a salt gradient or applied voltage, respectively. These synthetic nanoengines self-Arrange and operate autonomously in physiological circumstances, suggesting ways to developing Electricity-transducing motors at nanoscale interfaces.
Incredibly awesome, but that wasn’t genuinely where my curiosity lay. I planned to pioneer and I had the feeling which was now not feasible, since the most attention-grabbing fundamental insights had by now been uncovered. But my field had produced quite a few thrilling new equipment to evaluate unique molecules. I decided that I planned to utilize this to biology, to look at it from a physical viewpoint.’
An integrated microfluidic ceesdekker System for quantifying drug permeation throughout biomimetic vesicle membranes
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2013, managed shaping of Dwell bacterial cells into arbitrary shapes; and discovery of spontaneous fluctuations from the handedness of histone tetrasomes