The smart Trick of ceesdekker That Nobody is Discussing
The smart Trick of ceesdekker That Nobody is Discussing
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Employing single-molecule optical and AFM imaging and drive-spectroscopy approaches, we find to unravel the mechanistic facets of the structure and dynamics of chromosomes. Our investigate passions contain:
1996, 1st mesoscopic demand density waves devices; and very first electrical measurements on only one metal nanocluster concerning nanoelectrodes
‘It was simply just a make any difference of finding up a ebook on cell biology and starting to browse. I'd come from a world of extremely-substantial vacuums, cryostats and quantum phenomena, and now I was working at home temperature with molecular biology kits.
Non-equilibrium folding of individual DNA molecules recaptured as much as 1000 times in a solid state nanopore
2010, developed a fresh way (‘wedging transfer’) to control nanostructures; initially report of DNA translocation as a result of graphene nanopores; and realized hybrid nanopores by directed insertion of α-hemolysin into strong-state nanopores
SMC complexes can move Bodily roadblocks bigger than their ring size, indicating a nontopological system for DNA loop extrusion
Duration Charge of specific carbon nanotubes by nanostructuring Together cees dekker with the scanning tunneling microscope
Dynamic ParB–DNA interactions initiate and keep a partition condensate for bacterial chromosome segregation
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‘The fantastically subtle way during which components in mother nature functionality under no circumstances ceases to amaze me. If we fix the puzzle of how existence came into remaining, I be expecting that my amazement on the complexity of creation should have greater and with it my awe to the greatness from the Creator.’
Illustration (4) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is revealed in grey, the rim in the pore is highlighted in red, and a 3D rendering of your movement in the DNA rod is displayed.
Later on we spoke all over again briefly simply because Dekker felt that our discussion of his faith promptly turned purely philosophical, whereas In addition, it concretely can help him in his do the job.
Visualization of unstained DNA nanostructures with State-of-the-art in-aim transmission electron microscopy methods
At last, I'll briefly sketch some of our Suggestions to investigate the constructing of artificial cells, specially our to start with steps to establish artificial mobile division.